Decreased IRF7 Expression Contributes to Deficient IFN-α Production of Plasmacytoid Dendritic Cells in Chronic HIV-1 Infected Men who have Sex with Men
نویسندگان
چکیده
Abbreviation: HIV-1: Human Immunodeficiency Virus Type 1; CHI: Chronic HIV-1 Infection; PDCs: Plasmacytoid Dendritic Cells; IFN-α: Interferon-α; TLR: Toll-like Receptor; TLR7: Toll-like Receptor 7; TLR9: Toll-like receptor 9; IRF7: Interferon Regulatory Factor 7; NF-κB: Nuclear factor κB; NCs: Normal Controls; MSM: Men Who Have Sex With Man; PBMC: Peripheral Blood Mononuclear Cells; ICS: Intracellular Staining; SEM: Standard Error of the Mean
منابع مشابه
Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-α-producing and partially matured phenotype.
Plasmacytoid DCs (pDCs) are innate immune cells that are specialized to produce IFN-α and to activate adaptive immune responses. Although IFN-α inhibits HIV-1 replication in vitro, the production of IFN-α by HIV-activated pDCs in vivo may contribute more to HIV pathogenesis than to protection. We have now shown that HIV-stimulated human pDCs allow for persistent IFN-α production upon repeated s...
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